In the field of bioinformatics and computational biology, specialists collect, store, analyze, model, and present complex biological data to understand how individual components of biological systems and the interactions between them inform function at all levels of biological hierarchy. Through the combination of biological analysis and high-performance computing, critical contributions are made to biomedical, agricultural, and environmental sciences. The main objective of this doctorate is to educate the next generation of computational biologists for careers in academia, industry, and government. The program provides students with interdisciplinary academic training that includes fundamental bioscience courses as well as core and advanced courses in bioinformatics. The curriculum is designed to be completed in approximately two years. The completion of coursework, the comprehensive exam, and a successful dissertation proposal result in advancement to candidacy status. In the final phase of the program, students focus on research that culminates in a dissertation.

The program is structured to be accessible for full and part-time students. Because the program has a fully online option, students may choose to earn the doctoral degree entirely remotely or in a traditional face-to-face format. All courses are offered in hybrid, distance learning, or asynchronous formats without requiring students to travel to campus. Visit Mason Online for details.


University-wide admissions policies can be found in the Graduate Admissions Policies section of this catalog.

To apply for this program, please complete the George Mason University Admissions Application.


Applicants should have a bachelor's degree in biology, computer science, or a related field, with a minimum GPA of 3.25 in the last earned degree. Applicants should have taken courses in molecular biology, cell biology, biochemistry, genetics, calculus, physical chemistry, computer programming and data structures, and probability and statistics. Students with deficiencies in one or more of these areas may be admitted provisionally and required to take additional courses, some of which may not be applicable to the degree's course total. Students whose undergraduate record does not include basic biochemistry will be required to take a basic course prior to BINF 701 Systems Biology.

Application Requirements

To apply, prospective students should submit the George Mason University Admissions Application, a copy of official transcripts from each college and graduate institution attended, a current résumé, and an expanded goals statement. Applicants should also include three letters of recommendation. TOEFL or IELTS scores are required of all international applicants.

The GRE is not required for admission into this program.


For policies governing all graduate programs, see AP.6 Graduate Policies.

Reduction of Credits

For students entering the doctoral program with a master's degree in a related field from an institution of higher education accredited by a Mason-recognized U.S. institutional accrediting agency or international equivalent, the number of required credits may be reduced up to 30 credits, subject to approval of the program director and the college's associate dean for student affairs. See AP.6.5.2 Reduction of Credits for more information.

Banner Code: SC-PHD-BCB

Degree Requirements

Total credits: 72

Students should refer to the Admissions & Policies tab for specific policies related to this program.

Doctoral Coursework

Fundamental Bioscience Courses
BINF 701Systems Biology3
BINF 702Biological Data Analysis3
Core Bioinformatics Courses
BINF 690Numerical Methods for Bioinformatics3
BINF 705Research Ethics1
BINF 730Biological Sequence and Genome Analysis3
BINF 731Protein Structure Analysis3
BINF 740Introduction to Biophysics3
General Electives
Select 23-35 credits of approved general electives or independent research23-35
Lab Rotation3
Bioinformatics Lab Rotation (taken three times)
Colloquium in Bioinformatics (taken three times)
Total Credits48-60

Doctoral Committee and Advancement to Candidacy

By the end of the semester when coursework is completed, the student must form a doctoral committee made up of a minimum of three graduate faculty members and take a written comprehensive exam. The exam includes written and oral components. Upon passing the comprehensive exam and submitting an acceptable dissertation proposal, the student is advanced to doctoral candidacy to begin the dissertation writing phase.

Dissertation Research

A minimum of 12 and maximum of 24 combined credits from BINF 998 Doctoral Dissertation Proposal and BINF 999 Doctoral Dissertation may be applied toward satisfying doctoral degree requirements. Students must take at least 3 credits of BINF 999 Doctoral Dissertation.

Select 12-24 credits from the following:12-24
Doctoral Dissertation Proposal
Doctoral Dissertation
Total Credits12-24

Doctoral Dissertation

After advancing to doctoral candidacy, students work on their doctoral dissertation while enrolled in BINF 999 Doctoral Dissertation. The dissertation should represent a significant contribution that is suitable for publication in a refereed scientific journal. The dissertation must be defended in a public forum before the dissertation committee and other interested faculty.