The Office of Research has overall responsibility for the university's research enterprise. Working in an atmosphere characterized by its commitment to generate new knowledge through research and scholarship and to seed and support entrepreneurship and innovation to benefit society, Mason's researchers and scholars conduct their work in an array of disciplines and subject areas. The Office works to promote and optimize the success and impact of these endeavors and to create an environment that sustains the highest standards of ethical research and scholarship.

The Office establishes, with the advice of Mason’s Research Council, and administers the policies governing research and scholarship at the university. It also oversees the management of Mason's research programs, assists investigators seeking external funding, promotes interdisciplinary research, and ensures compliance with federal, state, and institutional regulations. Additional information about the units comprising the Office, and the resources and policies supporting researchers and scholars throughout the university, is available at the website.